Ashley Buckle is Head of Protein Engineering at Replay. He has more than three decades of expertise in structural biology and protein engineering, combining biochemistry, biophysical, structural, and computational approaches to attack important problems in biology. He trained at the MRC Centre for Protein Engineering in Cambridge, UK (1990-2003), under the supervision of Sir Alan Fersht, a pioneer of protein engineering. He was a Staff Scientist at the MRC Centre for Protein Engineering up until 2003, when he moved to Monash University, Melbourne Australia to start his own research group. He has published over 150 papers, and is a named author on several patents, encompassing: minichaperone refolding, hypoimmune iPS cells, development of activators of GAD65 as therapeutic agents in anxiety disorders, and highly stable monobodies.
Ashley currently holds an adjunct appointment at the Department of Biochemistry and Molecular Biology, Monash University, and is a founder of PTNG and Biovidera.