Replay
Toggle
Menu
Platforms
Products
Team
News
Reprogramming biology by writing and delivering big DNA
Applications
01.
Writing genes
1-5kb
Writing genes
1-5kb
Rapid and cost-effective gene synthesis
Synthetic gene library generation
Rewrite and optimise gene sequences
DropSynth™ technology
LASR™ technology
01 / 02
Applications
02.
Writing and delivering constructs
5-150kb
Writing and delivering constructs
5-150kb
In Vivo
Ex Vivo
Write and deliver big genes, genomic genes, and multiple genes
Complex regulatory elements and synbio circuitry
Multiplex transcription factors in conjunction with control elements
Polygenic medicine
synHSV™ Technology
Deliver big DNA to autologous, allogeneic, and iPSC-derived cell therapies
Write and install large constructs to replace multiplex editing
Enable extensively genomically rewritten iPSC-derived therapies
Regenerative medicine, CARs, TCRs
Multiple cell types
uCell™ Technology
01 / 02
Applications
03.
Writing simple genomes
150kb-10Mb
Writing simple genomes
150kb-10Mb
Viral genomes (EBV : 170kb)
Bacterial genomes (E.coli : 4.6mb)
Mini Y chromosome (Human Y : 57mb)
01 / 02
Applications
04.
Writing complex genomes
10mb-10gb+
Writing complex genomes
10mb-10gb+
Synthetic human chromosomes for iPSC-derived cell therapy
Synthetic plant, fungal, and mammalian genomes
01 / 02
About us
Authoring the next generation of genomic products, leveraging synthetic gene libraries, high payload delivery, and hypoimmunogenic technologies.
Meet the team
Latest news
All news
Cristian Massacesi, M.D., Appointed to Replay Board of Directors
Read More
25.05.2023
– NEWS
Replay Appoints Arun Balakumaran M.D., Ph.D as Chief Medical Officer
Read More
18.05.2023
– NEWS
Cell and gene therapy biotech creator Replay plucks Allogene CMO Arun Balakumaran to lead clinical trials
↳
endpts.com
18.05.2023
– MEDIA
Ask the Experts with Matthew Mulvey: What is “Big DNA”?
Read More
25.04.2023
– NEWS
Join Replay
Help us to author the future of genomic medicine
Open positions