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Reprogramming biology by writing and delivering big DNA
Applications
01.
Writing genes
1-5kb
Writing genes
1-5kb
Rapid and cost-effective gene synthesis
Synthetic gene library generation
Rewrite and optimise gene sequences
DropSynth™ technology
LASR™ technology
01 / 02
Applications
02.
Writing and delivering constructs
5-150kb
Writing and delivering constructs
5-150kb
In Vivo
Ex Vivo
Write and deliver big genes, genomic genes, and multiple genes
Complex regulatory elements and synbio circuitry
Multiplex transcription factors in conjunction with control elements
Polygenic medicine
synHSV™ Technology
Deliver big DNA to autologous, allogeneic, and iPSC-derived cell therapies
Write and install large constructs to replace multiplex editing
Enable extensively genomically rewritten iPSC-derived therapies
Regenerative medicine, CARs, TCRs
Multiple cell types
uCell™ Technology
01 / 02
Applications
03.
Writing simple genomes
150kb-10Mb
Writing simple genomes
150kb-10Mb
Viral genomes (EBV : 170kb)
Bacterial genomes (E.coli : 4.6mb)
Mini Y chromosome (Human Y : 57mb)
01 / 02
Applications
04.
Writing complex genomes
10mb-10gb+
Writing complex genomes
10mb-10gb+
Synthetic human chromosomes for iPSC-derived cell therapy
Synthetic plant, fungal, and mammalian genomes
01 / 02
About us
Authoring the next generation of genomic products, leveraging synthetic gene libraries, high payload delivery, and hypoimmunogenic technologies.
Meet the team
Latest news
All news
Rare Disease Day 2023: In conversation with Alex Silver
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28.02.2023
– NEWS
KKR-backed Replay and MD Anderson form new product company Syena to pioneer first-in-class TCR-NK cell therapy
Read More
14.02.2023
– NEWS
Replay Bio partners with MD Anderson’s Katy Rezvani, heads to clinic with new TCR NK cell company
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endpts.com
14.02.2023
– MEDIA
Replay targets genetic brain disorders with new gene therapy company, Kaleibe, utilising big DNA HSV technology
Read More
14.12.2022
– NEWS
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