Replay

HSV GENE THERAPY

Viral gene therapy is a therapeutic approach that utilizes viruses to deliver genetic material into cells, aiming to treat or prevent diseases at the genetic level. The viruses must be modified (engineered) to remove their disease-causing genes, while retaining their ability to infect cells. The engineered viruses, called viral vectors, carry a therapeutic gene that can replace or supplement a faulty gene in the patient’s cells. In the past, adeno-associated virus (AAV) vectors were the leading platform for viral gene therapy. The problem is, 83% of genes are too large to be contained within an AAV vector. We're focused on utilizing HSV's large cargo space to carry and delivery big genes to treat disease.

HSV

01 / 02
02 / 02

Delivering big DNA

HSV is capable of delivering up to 30x the payload of AAV. We can deliver big genes, genomic genes, and multiple genes, unlocking the promise of polygenic medicine.

HSV: 150kb vs. AVV: 4.8kb
HSV: 150kb vs. AVV: 4.8kb
HSV: 150kb vs. AAV: 5kb

Delivering big DNA

83% of genes are too big for AAV