Pushing the bounds of high payload delivery
There is a need for new technologies that allow safe, durable expression of genes and regulatory elements exceeding the payload of existing platforms. At Replay we are focussed on engineering HSV-1 to carry therapeutic payloads.
HSV
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Delivering big DNA
HSV is capable of delivering up to 30x the payload of AAV. We can deliver big genes, genomic genes, and multiple genes, unlocking the promise of polygenic medicine.
Delivering big DNA
83% of genes are too big for AAV
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