Replay

HSV GENE THERAPY

Viral gene therapy is a therapeutic approach that utilizes viruses to deliver genetic material into cells, aiming to treat or prevent diseases at the genetic level. Viruses are engineered to remove toxic genes, while retaining their ability to infect cells. Aeno-associated virus (AAV) vectors are the leading platform for viral gene therapy, but 83% of genes are too large to be contained within them. We're focused on utilizing HSV's large cargo space to delivery big genes to treat rare genetic diseases.

HSV

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Delivering big DNA

HSV is capable of delivering up to 30x the payload of AAV.

HSV: 150kb vs. AVV: 4.8kb
HSV: 150kb vs. AVV: 4.8kb
HSV: 150kb vs. AAV: 5kb

Delivering big DNA

83% of genes are too big for AAV