TCR-NK
NY-ESO-1 (New York Esophageal Squamous cell carcinOma 1) is a highly validated tumor target neoantigen with aberrant expression in numerous cancer cell types, including myxoid/round cell liposarcoma (89%), Neuroblastoma (82%), Synovial Sarcoma (80%) and Multiple Myeloma (60%). Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have established it as a compelling target for cancer immunotherapy.
synHSV™ Big DNA eye gene therapy
Stargardt disease is a genetic eye disease that causes retinal degeneration and vision loss. It is the most common form of inherited macular degeneration, affecting about 30,000 people in the U.S. The progressive vision loss is caused by the degeneration of photoreceptor cells in the central portion of the retina called the macula.
synHSV™ Big DNA skin gene therapy
Dystrophic Epidermolysis Bullosa causes the skin to be fragile and blister easily. Blisters and skin erosions form in response to minor injury or friction, such as rubbing or scratching. Severe cases of this condition involve widespread blistering that may lead to vision loss, scarring, and other serious medical problems.
synHSV™ Big DNA brain gene therapy
Parkinson's disease (PD) is a brain disorder that causes unintended or uncontrollable movements, such as shaking, stiffness, and difficulty with balance and coordination. Symptoms usually begin gradually and worsen over time. As the disease progresses, people may have difficulty walking and talking. Distinct genetic drivers cause about 10% to 15% of all Parkinson's.
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