Cristian Massacesi
Director

Dr. Massacesi is a member of the Replay Board of Directors. He is a leading expert in medical oncology, with over 20 years of research and drug development experience in the pharmaceutical industry. Dr. Massacesi is the Chief Medical Officer of AstraZeneca [LSE/STO/Nasdaq: AZN] and Alexion, where he oversees patient safety and quality assurance activities for the entire company portfolio – from investigational drugs to established products. He is also the Oncology Chief Development Officer at AstraZeneca, where he leads the global development and operations of its late-stage Oncology portfolio of innovative medicines and immunotherapies, comprising more than 160 studies spanning multiple indications. His role and responsibilities at AstraZeneca continue unchanged.

Prior to AstraZeneca, Dr. Massacesi held several other senior leadership roles. He was Vice President, and Medicine Team Leader Immuno-Oncology at Pfizer, where he led multiple development programs in lung cancer, head and neck cancer, and hematological malignancies, and supported the oncology business development and pipeline strategy.

Dr. Massacesi was also Vice President, and Senior Global Clinical Program Head for the Immunotherapy Centre of Excellence at Novartis, and the Oncology Global Development and Global Medical Affairs Paris Site Head. Prior to that, as Global Clinical Program Head, he led the company’s PI3K-inhibitors portfolio through clinical development, including registrational studies and submissions.

Dr. Massacesi began his Academic career at Marche Polytechnic University in Italy, where he worked in the Department of Medical Oncology and Radiotherapy. He holds postgraduate degrees from the School of Oncology and School of Forensic Medicine at Marche Polytechnic University and received his medical oncology training at the Royal Marsden Hospital in London, UK, the Kaplan Comprehensive Cancer Center, NY, USA, and the European Institute of Oncology, Italy.

Dr. Massacesi has authored over 50 peer-reviewed papers and 100 conference abstracts on a wide range of cancer topics and lectured on subjects that include immunotherapy clinical trials, breast cancer, and the clinical development of PI3K-inhibitors. Dr. Massacesi has authored multiple patents on cancer treatment combinations and regimens.